
Perilla frutescens
Also known as Shiso, Zi Su, Psyllium, plantain or ispaghula, Black, zǐ sū zǐ, zǐ sū yè, sū yè.
TCM: Zi Su Ye (leaf) releases exterior wind-cold, harmonizes stomach Zi Su Zi (seed) descends Lung Qi, resolves phlegm Perilla ketone may cause pulmonary toxicity at high doses (livestock data) human safe limit leaves ≤5g/day. GRAS for some components.

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| Preparation | As written | Metric |
|---|---|---|
| Tea | Tea (leaf): 5-9g dried/day | 5000-9000 mg |
| Tincture | Tincture (leaf): 5-15mL/day | 5-15 mL |
| Decoction | Decoction (seed/leaf/stem): 3-9g/day | 3000-9000 mg |
| · Perilla leaf: extract equivalent to 4-9 g/day | 4000-9000 mg | |
| 3.0% polyphenols):100-150 mg/day (Oryza Co | 100-150 mg | |
| · External use (dental caries and periodontal disease): 80-160 mg defatted perilla seed daily delivered directly into the oral cavity in the form of toothpaste, chewing gum or mouth rinse | 80-160 mg |
Doses are reproduced from the sources for practitioners and are not a recommendation for any person.
Clinical Notes. TCM: Zi Su Ye (leaf) releases exterior wind-cold, harmonizes stomach Zi Su Zi (seed) descends Lung Qi, resolves phlegm Perilla ketone may cause pulmonary toxicity at high doses (livestock data) human safe limit leaves ≤5g/day. GRAS for some components.
primary-actions. Perilla acts primarily as: Anti-inflammatory, Antioxidant, Antiallergic, Antimicrobial, Expectorant, Carminative. Secondary actions include Antitussive, Antidepressant, Neuroprotective, Hepatoprotective, Hypoglycemic.
indications. Perilla is traditionally indicated for: Inflammatory bowel disease, Atopic dermatitis, Depression, Constipation, Rhinitis, Food poisoning, Hyperlipidemia, Allergies, Bronchitis, Asthma, Chest stuffiness, Nausea, Anxiety, Fish poisoning, Cough, and 26 further conditions.
dose-reference. Reference preparation/dosing for Perilla: Tea (leaf): 5-9g dried/day; Tincture (leaf): 5-15mL/day; Decoction (seed/leaf/stem): 3-9g/day; Seed oil: dietary amounts
Perilla stands in 108 documented formulas in the library, among them ùng gián công chi tāng, hua gài sǎn, jià wèi xiang sù sǎn, xiang sù sǎn, xiang sù công chi tāng, xìng sù yìn.

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