Goldenseal

Clinical Notes. Endangered plant (CITES Appendix II) - use cultivated/organic sources only Short-term use (max 3 weeks with breaks) Berberine has poor systemic absorption, best for local mucosal/topical use Synergizes with Echinacea for infections and flavonoids to enhance antimicrobial effects via efflux pump inhibition Monitor blood pressure Traditional Eclectic 'king of mucous membrane remedies'

Clinical Notes. Overharvested wild populations CITES Appendix II prefer cultivated frequent adulteration with leaf or other Berberis (detect via hydrastine & absence palmatine) short-term use berberine absorption increased in inflammation [[AHP]] [[NCCIH]

Therapy. External. Hydrastis is one of our most efficient topical medicines when applied in disorders of the mucous membranes; and is occasionally of service upon the skin. It is of most importance perhaps in ophthalmic practice, being a thoroughly effective subastringent and soothing agent in acute and subacute catarrhal and follicular conjunctivitis.

Therapy. In its therapeutic influence its widest range of action is upon the stomach, in functional disorders of that organ. It is the most natural of stimulants to the normal function of digestion. Its influence upon the mucous surfaces renders it most important in catarrhal gastritis and gastric ulceration.