
Mandragora officinarum
Also known as European Mandrake.
Highly toxic Solanaceae herb with historical use as anesthetic and analgesic but considered UNSAFE for medicinal use by modern authorities due to risk of fatal poisoning no approved herbal medicinal products in EU prescription-only in UK for related species

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Ask HerbertRecognised toxicity. This plant carries a toxicity flag in the record; it is for trained practitioners only.
Low dose botanical. Used in drop doses in the classical practice; not a plant to dose freely.
Pregnancy: Pregnancy Caution
Breastfeeding: lactation
The record lists 13 contraindications; open the plate in the library to read them in full.
| Preparation | As written | Metric |
|---|---|---|
| Historical: Root juice or wine 45ml pre-surgery | 45-45 mL | |
| Oral root powder max | Oral root powder max 0.125g (2 grains) | 125-125 mg |
Doses are reproduced from the sources for practitioners and are not a recommendation for any person.
Clinical Notes. Highly toxic Solanaceae herb with historical use as anesthetic and analgesic but considered UNSAFE for medicinal use by modern authorities due to risk of fatal poisoning no approved herbal medicinal products in EU prescription-only in UK for related species
indications. Mandrake is traditionally indicated for: Rheumatic pain, Constipation, Skin ulcer, Stomach ulcer, Melancholy, Convulsions, Colic, Hay fever, Mania, Pain, Asthma, Whooping cough, Anxiety, Insomnia, Restlessness, and 2 further conditions.
constituents. Notable constituents of Mandrake include: Tropane alkaloids (atropine, hyoscyamine, scopolamine, scopine, cuscohygrine, apoatropine, 3-alpha-tigloyloxytropane, 3-alpha,6-beta-ditigloyloxytropane, belladonnines), sitosterol, beta-methylesculetin (scopoletin.
dose-reference. Reference preparation/dosing for Mandrake: Historical: Root juice or wine 45ml pre-surgery; Oral root powder max 0.125g (2 grains); Modern: Not recommended due to toxicity; Hyoscine extracted for clinical use

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