
Sceletium tortuosum
Also known as Kougoed, Channa.
Used traditionally by Khoi-San peoples chewed fermented aerial parts for mood elevation, stress reduction, pain relief, appetite suppression during hunting Clinically studied extracts (Zembrin) show anxiolytic effects via serotonin reuptake inhibition and PDE4 inhibition in healthy subjects Fermentation process increases alkaloid content

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| Preparation | As written | Metric |
|---|---|---|
| Dried powder capsules | Dried powder capsules 25-50 mg standardized extract daily | 25-50 mg |
| Zembrin | Zembrin 8-25 mg daily (clinical | 8-25 mg |
| Chewed fresh/fermented (50-400 mg) |
Doses are reproduced from the sources for practitioners and are not a recommendation for any person.
Clinical Notes. Used traditionally by Khoi-San peoples chewed fermented aerial parts for mood elevation, stress reduction, pain relief, appetite suppression during hunting Clinically studied extracts (Zembrin) show anxiolytic effects via serotonin reuptake inhibition and PDE4 inhibition in healthy subjects Fermentation process increases alkaloid content
indications. Kanna is traditionally indicated for: Thirst, Toothache, Stress, Anxiety, Headache, Mood imbalance, Hunger, Respiratory disease, Tension, Insomnia, Abdominal pain, Fatigue, Depression, Infection, Inflammation, and 2 further conditions.
dose-reference. Reference preparation/dosing for Kanna: Chewed fresh/fermented (50-400 mg); Dried powder capsules 25-50 mg standardized extract daily; Tea decoction; Tincture; Zembrin 8-25 mg daily (clinical
safety-cautions. Kanna - Contraindications: SSRIs, MAOIs, Serotonergic drugs | Side effects: Headache, Nausea, Loss of appetite (infrequent | Safety flags: not considered safe in pregnancy; not considered safe during lactation.

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