
Aesculus hippocastanum
Raw seeds, bark, flowers contain toxic esculin use only processed, defatted seed extracts standardized to triterpene glycosides (aescin) approved by / for seed extract in chronic venous insufficiency bark traditionally used but insufficient evidence

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| Preparation | As written | Metric |
|---|---|---|
| Dry extract | Dry extract (DER 4.5-5.5:1 or 3-6:1, ethanol 40-80% V/V, standardized to 16-20% or 6.5-10% triterpene glycosides as aescin or protoaescigenin), 50-150 mg aescin equivalent daily in divided doses | 50-150 mg |
| topical dry extract or gel | topical dry extract or gel (2% aescin) 1-3x daily on intact skin | |
| Fruit 0.2-1.0 g three times daily .(G49) Preparations Extracts equivalent to 50 -150 mg triterpenes calculated as aescin, in divided doses | 200-1000 mg | |
| · CVI: HCSE standardised to 50-100 mg escin twice daily | 50-100 mg | |
| · Australian manufacturers recommend 2-5 mL/day of 1:2 liquid extract | 2-5 mL | |
| · 1-2 g dried seed daily. | 1000-2000 mg |
Doses are reproduced from the sources for practitioners and are not a recommendation for any person.
Clinical Notes. Raw seeds, bark, flowers contain toxic esculin use only processed, defatted seed extracts standardized to triterpene glycosides (aescin) approved by / for seed extract in chronic venous insufficiency bark traditionally used but insufficient evidence
Action and Therapy. The action and therapeutic uses of hippocastanum are closely similar to those of Aesculus glabra, which see. By some it is believed to have a somewhat stronger action upon the venous circulation. It is often a remedy of value in neuralgia of the abdominal and pelvic viscera, when there is plethora.
Properties and Uses. The bark is a narcotic astringent, and is not a curative agent; yet some have commended it as a tonic in intermittents. The rind of the nuts is a stronger narcotic- possessing about one-third the strength of opium.
Action, Medical Uses, and Dosage. This agent influences the nervous and circulatory systems, having a selective affinity for the portal circulation. In over-doses it affects the cerebro-spinal system somewhat after the manner of nux vomica.
Drawn from Cook's Physio-Medical Dispensatory; King's American Dispensatory, 18th edition (Felter and Lloyd); Felter's Eclectic Materia Medica, Pharmacology and Therapeutics, and the Bountiful Herbs editorial.

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