Western Herbalism
Madagascar Periwinkle
Catharanthus roseus
Also known as Rosy Periwinkle.
Madagascar Periwinkle acts primarily as: Antineoplastic (vinblastine, vincristine - mitotic spindle inhibitors), Hypoglycemic, Antimicrobial, Antioxidant. Secondary actions include Antineoplastic, Hypoglycemic, TOXIC - not for casual internal use.
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Indications what the tradition reached for it in
- Botanical source of the vinca alkaloids vincristine and vinblastine (leukemia, Hodgkin and non-Hodgkin lymphoma - pharmaceutical)
- Traditional folk use for diabetes mellitus
- Hypertension
- Skin infections and wounds (topical)
- NOT appropriate for casual internal self-dosing
Safety
Low dose botanical. Used in drop doses in the classical practice; not a plant to dose freely.
Pregnancy: Not for use in pregnancy
Breastfeeding: Lactation (source flag notSafeInLactation)
The record lists 7 contraindications; open the plate in the library to read them in full.
From the sources
primary-actions. Madagascar Periwinkle acts primarily as: Antineoplastic (vinblastine, vincristine - mitotic spindle inhibitors), Hypoglycemic, Antimicrobial, Antioxidant. Secondary actions include Antineoplastic, Hypoglycemic, TOXIC - not for casual internal use.
indications. Madagascar Periwinkle is traditionally indicated for: Botanical source of the vinca alkaloids vincristine and vinblastine (leukemia, Hodgkin and non-Hodgkin lymphoma - pharmaceutical), Traditional folk use for diabetes mellitus, Hypertension, Skin infections and wounds (topical), NOT appropriate for casual internal self-dosing.
constituents. Notable constituents of Madagascar Periwinkle include: Bisindole (dimeric) alkaloids: vinblastine, vincristine, vindesine, Monoterpene indole alkaloids: vindoline, catharanthine, ajmalicine, serpentine, Flavonoids, Phenolic acids.
dose-reference. Reference preparation/dosing for Madagascar Periwinkle: Not recommended as a home internal botanical; The purified vinca alkaloids are intravenous chemotherapeutics dosed by oncology; Traditional antidiabetic leaf decoctions have been used but carry cytotoxic risk and are not advised without supervision
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