
Hericium erinaceus
Limited large-scale human RCTs Promising preclinical and small clinical data for neuroprotection and GI support Constituents like hericenones/erinacines stimulate NGF synthesis and cross BBB Traditional use in TCM for Qi deficiency, digestive tonification, shen calming. Frontiers Systematic World J Gastroenterol

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| Preparation | As written | Metric |
|---|---|---|
| Dried fruiting body powder | Dried fruiting body powder 3-5 g/day | 3000-5000 mg |
| 96% dry powder 250 mg 3x/day (750 mg total) | 250-250 mg | |
| Fruiting body | Fruiting body 2 g/day | 2000-2000 mg |
Doses are reproduced from the sources for practitioners and are not a recommendation for any person.
Clinical Notes. Limited large-scale human RCTs Promising preclinical and small clinical data for neuroprotection and GI support Constituents like hericenones/erinacines stimulate NGF synthesis and cross BBB Traditional use in TCM for Qi deficiency, digestive tonification, shen calming. Frontiers Systematic World J Gastroenterol
primary-actions. Lion's Mane acts primarily as: Nervine, Nootropic, Neuroprotective, Anti-inflammatory, Immunomodulator. Secondary actions include Antioxidant, Gastroprotective, Antineoplastic, Gut microbiota modulator.
indications. Lion's Mane is traditionally indicated for: Gastric cancer, Alzheimer's disease, Cognitive impairment, Helicobacter pylori infection, Chronic gastritis, Stress, Epigastric pain, Anxiety, Memory loss, Inflammatory bowel disease, Atrophic gastritis, Neuropathic pain, Colorectal cancer, Gastric ulcer, Insomnia, and 15 further conditions.
constituents. Notable constituents of Lion's Mane include: Hericenones (A-H from fruiting body), Erinacines (A-K, P-S from mycelium), β-glucans, Steroids (ergosterol), Alkaloids (hericirine, pseurotin A.

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